This game is brilliant. Released some years ago, it's an Action RPG where you control Nier (though you can put his name in), either a teenager brother to Yonah, or middle-aged father to Yonah, who is a sick little girl you do everything to find a cure for. The world is damned; humanity's days are numbered. Ever play Drakengard and earned the fifth, non-canon ending? This game is the sequel to that. There's two versions to the game - Replicant and Gestalt. Replicant is teenager, Gestalt is adult, and while the Japanese release considers Replicant to be the canon version, Gestalt is the only version which was ever translated.
Your daughter, Yonah, is sick with the black scrawl, a disease that causes black symbols to appear on a person's flesh and has a 100% mortality rate. Once infected, it's not a matter of if, but when you die. Nier thus begins to travel a lot in the hopes of finding a cure for his daughter/sister's ailment. Shortly into the game, you find Weiss, a talking book. This is the scene you're treated to upon first starting up the game, and it really showcases why this game is awesome:
http://www.youtube.com/watch?v=6SCcbmFBPHQIf you've never played this game, I recommend it. The gameplay is solid, the plot is nothign special, the characters are great, but the music is amazing. And, mostly:
WEISS, YOU DUMBASS. START MAKING SENSE YOU ROTTEN BOOK OR YOU'RE GONNA BE SORRY.