Well, the thing is, even if there would be a audible difference between lossless and 320 (most of the time, there isn't, unless you have a very bad compressor), you probably would even really hear the difference anyways on mainstream audio hardware. Besides, as far as I'm concerned, the usual downmix bitrate is 192.
So, lossless audio is, most of the time, a waste of harddrive place, unless you want to work with the audio files, like when you are a DJ.
I myself use aac (no clue why, kinda got used to it) with 320 and am happy with it.