Yes, DRGSS will change the key for the Game.exe. You should be able to test that easy enough by attempting to use with an unmodified RGSS102. If the game runs normally after you change the key, then something didn't get done right. I the game crashes, then Game.exe has been successfully modified.
Now, I believe Aspac is what RGSS102 is packed with, use the Aspac stripper to open it up, find the DEADCAFE key, change it to whatever you used in the Game.exe, and save. Now you should be able to repackage the DLL with your choice, place it in your game folder with the Game.exe, and run them successfully.
I imagine that there are going to be packers that are incompatible, so you may need to try a few until you find one that works.