Yes, I save after editing. And I've tried Saving As, Renaming, Copying and moving the file. It always has the same problem.
I've only found one way to fix it and that's to "cut" the image in it's entirety out of the edited image, Close the image (without saving), deleting the image from the directory and out of RPGmakers memory, and then starting a new image in PSP and pasting the cut image into the new one and resaving it under an all new name.
But it's a Hell of a bother just to fix this "Ghosting" that I can't figure out the cause.